法國Biospace Lab 前身為Biospace measures 公司，由諾貝爾物理學獎得者喬治•夏帕克教授根據(jù)其在高能物理和粒子檢測方面的研究發(fā)現(xiàn)，于1989年組建成立。喬治•夏帕克教授及其團隊致力于生物影像工具的研究開發(fā)。公司成立以來，積極與醫(yī)學、藥學和其它領域的科研機構合作，力求滿足用戶對生物醫(yī)學影像儀器的實際需求。目前，Biospace Lab已經(jīng)發(fā)展了多種用于小型動物成像儀器，并擁有自己的技術。

Biospace Lsb致力于高性能臨床前實驗影像儀器的研制，成功開發(fā)出用于小型動物體內、體外和活動動態(tài)成像的成像系統(tǒng)。目前，該成像系統(tǒng)已經(jīng)在世界藥物公司和研究中心投入使用。

Biospace Lab的研發(fā)和生產(chǎn)總部位于法國巴黎，在歐洲、北美和亞洲均設有分公司。所有產(chǎn)品，包括其設計、生產(chǎn)、銷售、安裝和售后服務均符合ISO9001：2000認證規(guī)范。

PhotonIMAGER™ Dynamic optical imaging systems The PhotonIMAGERTM is a modular system for the non-invasive detection, localization and quantification of dynamic optical signal from live animals. A unique photon counting technology makes it extremely sensitive from the very start of image acquisition and enables the unparalleled kinetic recording of dynamic processes without the need for setting acquisition time, or pixel binning prior to imaging. The PhotonIMAGERTM continuously displays the light distribution during an experiment and image acquisition can be stopped at any time. This is a key advantage for luminescence imaging and can open new horizons for fluorescence imaging. Unlike other Pre-Clinical Imaging systems, the dynamic imaging capability of the PhotonIMAGER delivers impressive performance, whilst its modular design philosophy ensures that the systems capabilities can be extended, as further state-of-the-art imaging technologies become available. Biospace Lab offers two PhotonIMAGER systems and many combinations of modules, so you can adapt your choice to your needs. The PhotonIMAGER Optima system is a fully comprehensive solution for advanced in vivo optical imaging applications and is unequalled in its performance. The PhotonIMAGER RT system is a modular entry level solution for routine in vivo luminescence and fluorescence imaging applications.

PhotonIMAGER™
Dynamic Optical Imaging Systems for Fluorescence and Luminescence
 

The Photon Imager is a dynamic, modular system for the non-invasive detection, localization and quantification of dynamic optical signal - bioluminescence or fluorescence – from live animals. A unique photon counting technology makes it extremely sensitive from the very start of image acquisition and enables the unparalleled kinetic recording of dynamic processes without the need for setting acquisition time, or pixel binning prior to imaging. The PhotonIMAGER™ continuously displays the light distribution during an experiment and image acquisition can be stopped at any time. This is a key advantage for luminescence imaging and can open new horizons for fluorescence imaging. Unlike other Pre-Clinical Imaging systems, the real-time imaging capability of the PhotonIMAGER™ delivers impressive performance, whilst its modular design philosophy ensures that the systems capabilities can be extended, as further state-of-the-art imaging technologies become available.

Key Benefits of the PhotonIMAGER™ systems:

Easy Bioluminescence & Fluorescence Imaging
Unmatched Performance & accuracy
Real-time imaging capability
Modular philosophy
Ease of use


 

Easy Luminescence & Fluorescence Imaging

- Full spectrum imaging capability from blue to near-infrared in luminescence and fluorescence: Continuous selection of excitation wavelength from 450 up to 1000 nm
- Equipped with up to 10 band pass emission filters
- Automated autofluorescence substraction
- Spectral Unmixing
- Multilabeling Capacities
- From whole body to cell dimensions


 

High Sensitivity with an Intensified CCD camera

The PhotonIMAGER™design incorporates an intensified CCD camera, which makes it highly sensitive from the very first moments of image acquisition. iCCD technology amplifies all light emitted from the specimen by a factor 106; making the Photon Imager one of the most sensitive systems on the market for detection of low signal levels. Read more about the operating principles

 

- Detection of weak signals
- Negligible read out noise
- No more pixel binning and exposure time settings prior to imaging
- Acquisition from the very first second
- High Temporal Resolution of 23ms


Accurate signal localisation and quantification

 

Outstanding dynamic range
The PhotonIMAGER™ design ensures signal intensification by a factor of 106 and as a consequence, the PhotonIMAGER™ is the most sensitive system on the market for detection of weak light signals. Furthermore, users of the PhotonIMAGER™ can rely on an unequalled linear dynamic range: bioluminescence expression in tissues can thereby be followed, quantified and compared; from early detection of weak signal, through to later development of higher signal strength.

4-View and 3D imaging
The 4 View module helps increasing the analysis accuracy and relevance of your acquisitions. It offers a precise quantification by providing you not only one but several views of your animal （dorsal, ventral, and lateral views） simultaneously and in real time. The 4-View module is an excellent tool for a better localization of optical signals. Read more

With the 3D Pack installed, the PhotonIMAGER™ retains its real-time imaging capability; making dynamic 3-dimensional bioluminescence signal measurement over time （4D Imaging） a reality. Read more

Dynamic imaging capability

Thanks to its high temporal resolution and excellent sensitivity the PhotonIMAGER™continuously displays the light distribution from the first seconds of the experiment and can be stopped at any time. The dynamic imaging capability of the PhotonIMAGER™ system allows the signal kinetics to be followed precisely and independently, even when the signal is weak. It provides precise control over the time-zone selected for the measurement of each ROI, both during and following signal acquisition. The ideal signal measurement window can always be accuray selected for each animal or anatomical region in turn

- Visualize results in seconds
- Follow your acquisition in real-time and stop acquisition at any time
- No more guessing: Acquisition time or pixel binning settings prior to imaging is not necessary. - - Bias linked to bioluminescent reaction kinetics are suppressed
- No need to assume a hypothethical output curve as the actual kinetic curves are availabe
- Allows the recording of fast signal kinetics

Read more about the dynamic imaging capability（http://www.biospacelab.com/m-98-dynamic-optical-imaging.html）

A modular system for all applications -
build your own system adapted to your research

The modular philosophy of the PhotonIMAGER™ allows you to keep up with the latest developments in imaging technologies – existing optional modules and future options can be added to the basic instrument configuration.
Optical imaging has never been easier: change modules quickly, chose your module and acquisition mode on the touchscreen and start acquisition

Macrolens module（http://www.biospacelab.com/m-88-macrolens-module.html） for high resolution optical imaging
In Actio module（http://www.biospacelab.com/m-56-in-actio-module.html） for imaging of freely moving animals
4-View - 3D module（http://www.biospacelab.com/m-89-4-view-module.html） for an even better localization and quantification of optical signals
X-Ray module（http://www.biospacelab.com/m-91-x-ray-module.html） for a better anatomical localization of optical signals


Ease of use

- High throughput system for longitudinal studies – up to 5 mice at the same time
- Ease of manipulation - sliding stage, continuously variable field of view
- Designed for maintenance of animal welfare - thermoregulated stage, anaesthesia system
- Multiple imaging modalities and comprehensive analysis by the M3Vision™ Software

詳見：http://www.biospacelab.com/fichiers_site/a1908bio/contenu_pages/Brochure_PhotonIMAGER.pdf