 | 培安有限公司 |
會(huì)員.png)
010-65528800
高 （市場(chǎng)部）
- 電話：
- 010-65528800
- 手機(jī)：
- 售后電話：
- 010-64278205
- 傳真：
- 010-65519722
- 聯(lián)系我時(shí)，
- 告知來自化工儀器網(wǎng)
- 個(gè)性化：
- www.pynnco.net
- 商鋪網(wǎng)址：
- http://m.true-witness.com/st26894/
- 公司網(wǎng)站：
- http://www.pynnco.com
Peptoids的微波合成
閱讀：2661發(fā)布時(shí)間：2012-6-29
INTRODUCTION
Peptoids are polymers of various （N-alkyl） glycines.1 While they are similar in structure to peptides （Figure 1）, peptoids lack a peptide bond making them resistant to proteolytic activity in vivo1,2. This stability makes peptoids an attractive peptidomimetic target for drug discovery and development.
Figure 1. Comparison of peptide and peptoid structure.
Peptoids are generally synthesized through a “sub-monomer” process consisting of two steps; an acylation step using bromoacetic acid and N,N’-diisopropylcarbodiimide （DIC） followed by reaction with a primary amine via nucleophilic displacement of the bromide （Figure 2）.1
Figure 2. General synthesis of peptoids.
Because many structurally diverse monosubstituted amines are commercially available, peptoids with a wide variety of side chains can be readily synthesized.2,3 However, conventional synthesis of peptoids can take up to three hours per residue.1 Microwave irradiation has been shown to significantly.
Figure 3. 9-mer peptoid.
更多詳情，請(qǐng)培安公司：
：北京： 上海： 成都： 廣州：
: sales@pynnco.com ：www.pynnco.com
以上信息由企業(yè)自行提供，信息內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé)，化工儀器網(wǎng)對(duì)此不承擔(dān)任何保證責(zé)任。 溫馨提示：為規(guī)避購(gòu)買風(fēng)險(xiǎn)，建議您在購(gòu)買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。
