13BEK001BeKm-1

 BeKm-1 

Selective blocker of ERG1 channel(鉀通道ERG1選擇性阻斷劑)

BeKm-1 toxin is a peptide toxin that has been isolated from the venom of the Central Asian scorpion Buthus eupeus. toxin has been reported to be a highly selective inhibitor of the human ether-a-go-go ERG1 channel (hERG1) .  inhibits hERG1 channels expressed in HEK-293 cells with an IC₅₀ of 3.3 nM, but has no effect at 100 nM on human EAG, human SK1, rat SK2, human IK, human BK, KCNQ1/KCNE1, KCNQ2/KCNQ3, and KCNQ4 channels. It has also minimal effects on rat ELK1 channel.  inhibits the human ERG1 + KCNE1 combination transiently expressed in HEK-293 cells with an IC₅₀ value in the range of 10 to 30 nM.  toxin preferentially blocks human ERG channel through the closed (resting) state, although some open channel blockade is also reported to occur.

技術(shù)資料

氨基酸序列：

Arg-Pro-Thr-Asp-Ile-Lys-Cys⁷-Ser-Glu-Ser-Tyr-Gln-Cys¹³-Phe-Pro-Val-Cys¹⁷-Lys-Ser-Arg-Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys²⁸-Val-Asn-Gly-Phe-Cys³³-Asp-Cys³⁵-Phe-OH

二硫鍵：Cys⁷-Cys²⁸, Cys¹³-Cys³³, and Cys¹⁷-Cys³⁵  

長度 (aa)： 36  

分子式： C₁₇₄H₂₆₁N₅₁O₅₂S₆  

分子量：4091.70 Da  

外觀： White lyophilized solid 

可溶性：water and saline buffer 

CAS 號：Not available 

來源： Synthetic  

純度： > 97%

產(chǎn)品信息