活化半胱胺酸蛋白酶蛋白-9抗體；Caspase-9說明書

產(chǎn)品編號 bs-0049R 
中文名稱 活化半胱胺酸蛋白酶蛋白-9抗體；Caspase-9
別    名 Caspase-9 subunit p35; Apaf-3; APAF 3; APAF3; Apoptosis related cysteine peptidase; Apoptotic protease activating factor 3; Apoptotic protease MCH 6; Apoptotic protease MCH6; CASP 9; CASP9; Caspase 9; Caspase 9 apoptosis related cysteine protease; Caspase 9 precursor; Caspase 9c; Caspase9; Caspase9 subunit p10; ICE LAP6; ICE like apoptotic protease 6; RNCASP9; MCH 6; MCH6; OTTHUMP00000044594; CASP9_HUMAN.  
研究領域 腫瘤  細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  細胞凋亡   
抗體來源 Rabbit 
克隆類型 Polyclonal 
交叉反應 Human, Rat, Dog,  (predicted: Mouse, Cow, ) 
產(chǎn)品應用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. 
分 子 量 35/50kDa 
細胞定位 細胞漿  
性    狀 Liquid 
濃    度 1mg/ml 
免 疫 原 KLH conjugated synthetic peptide derived from human Caspase-9 subunit p35:11-120/416  
亞    型 IgG 
純化方法 affinity purified by Protein A 
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 
PubMed PubMed 
產(chǎn)品介紹 Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, BclXL, cIAP1, cIAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf1/cytochrome c complex, and following cleavage by Apaf1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase