CD44V4抗體 返回列表頁

英文名稱 CD44v4
中文名稱 CD44V4抗體
別    名 CD44 antigen; CD44 molecule; Heparan sulfate proteoglycan; PGP1; CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; Pgp1; CD44 antigen isoform 4 precursor; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteoglycan 8; cell surface glycoprotein CD44; GP90 lymphocyte homing/adhesion receptor; heparan sulfate proteoglycan; hyaluronate receptor; Hermes antigen; CD44 antigen; homing function and Indian blood group system; epican; phagocytic glycoprotein 1; extracellular matrix receptor III.
 CD44V4抗體說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  細胞生物  細胞膜受體  細胞表面分子  糖蛋白  內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Dog, Horse, Rabbit, 
產(chǎn)品應用 ELISA=1:500-2000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD44v4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 產(chǎn)品介紹 background:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq].

Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Subcellular Location:
Membrane.

Tissue Specificity:
Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Post-translational modifications:
Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
N-glycosylated.
O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s).
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

Similarity:
Contains 1 Link domain.

Gene ID:
960

Database links:

Entrez Gene: 100034221 Horse

Entrez Gene: 960 Human

Entrez Gene: 12505 Mouse

Omim: 107269 Human

SwissProt: Q05078 Horse

SwissProt: P16070 Human

SwissProt: P15379 Mouse

Unigene: 502328 Human

Unigene: 423621 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. xy-0313R calf thymus DNA小牛胸腺DNA抗體
xy-15060R C1orf2261號染色體開放閱讀框226抗體
xy-1508R Cathepsin L組織蛋白酶L抗體
xy-2937R CK II beta絲/蘇氨酸蛋白激酶II β抗體(casein kinase IIβ)
xy-2043R CK18細胞角蛋白18抗體
xy-6067R CD109轉化生長因子β1結合蛋白抗體
xy-15141R C22orf4522號染色體開放閱讀框45抗體
xy-15136R C22orf3222號染色體開放閱讀框32抗體
xy-2487R CD5LCD5L抗體
xy-2488R CD6CD6抗體
xy-2489R CD9CD9蛋白抗體
xy-2490R CD23CD23/FcεRII抗體
xy-2491R CD27CD27抗體
xy-2495R CD30CD30抗體
xy-2496R CD43CD43抗體
xy-2497R CD48CD48抗體
xy-2507R CD44 CD44抗體
xy-2508R CD11c整合素αX抗體
xy-2514R CCR5/CD195細胞表面趨化因子受體5抗體
xy-2515R CD2CD2抗體
xy-0274R C PeptideC-肽抗體
xy-0062R Calretinin鈣結合蛋白抗體
xy-0155R CRPC-反應蛋白抗體
xym-0391M CRP(C11F2)C-反應蛋白單克隆抗體
xy-0035M CREB-1環(huán)腺苷酸應答元件結合蛋白抗體
xy-0246R CRF促腎上腺皮質激素釋放因子抗體
xy-0382R CRF促腎上腺皮質激素釋放因子抗體
xy-15210R C5orf545號染色體開放閱讀框54抗體
xy-2474R CD93CD93抗體
xy-2476R CCL6嗜酸粒細胞趨化蛋白CCL6抗體
xy-15254R C6orf816號染色體開放閱讀框81抗體