MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務。

Folinic acid calcium

CAS No. : 1492-18-8

產(chǎn)品活性：Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶點：Antifolate  |  Endogenous Metabolite

結(jié)構(gòu)分類：酮、醛、酸

In Vitro: MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .

In Vivo: Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).

相關(guān)產(chǎn)品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  D-Valine-d₈  |  D-α-Hydroxyglutaric acid disodium  |  Nicotinamide N-oxide  |  Deoxycholic acid-d₅  |  Doxorubicin-¹³C,d₃ (TFA)  |  Palitantin  |  Estradiol hemihydrate  |  Adrenaline sulfate  |  Oleic acid-¹³C  |  Dextranase  |  H2S Donor 5a  |  Methylmalonic acid  |  Glycine, N-(aminoiminomethyl)-N-methyl-¹³C  |  Dihydroxyacetone phosphate  |  Sphingomyelin  |  (-)-Jasmonoyl-L-isoleucine  |  Octanoic acid-d₂  |  Vardenafil-d₅  |  N-Acetyllactosamine  |  D-Arabitol-¹³C  |  Imidazole  |  L-Tartaric acid diammonium  |  i-Inositol  |  Tryptophol  |  L-Aspartic acid  |  Indolelactic acid  |  6-Mercaptopurine-¹³C₂,¹⁵N  |  D-Sorbitol-d₈  |  Octanoic acid-d₃  |  Dinoprost-d₄

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應用于新藥研發(fā)、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業(yè)技術(shù)服務；
•   設有專業(yè)的實驗中心和嚴格的質(zhì)控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤最新的制藥及生命科學研究進展，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機構(gòu)建立了長期的合作。