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Omidenepag isopropyl

產(chǎn)品活性：Omidenepag isopropyl 是選擇性的，非前列腺素的 EP2 受體激動劑。Omidenepag isopropyl 在角膜穿透過程中轉(zhuǎn)化為活性產(chǎn)品 Omidenepag，Omidenepag 是高度選擇性的 EP2 受體激動劑。Omidenepag isopropyl 對 EP1，EP2 和 FP 受體有弱親和力。Omidenepag isopropyl 可以降低眼內(nèi)壓 (IOP)，有潛力用于青光眼的研究。

研究領(lǐng)域：GPCR/G Protein

作用靶點：Prostaglandin Receptor

In Vivo: Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP change after drug administration was compared to the predosing baseline value established on day 1.?Omidenepag isopropyl also shows significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist , with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models.
In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow.

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