目錄:MedChemExpress LLC>>信號通路>> Centrinone | MedChemExpress
| CAS | 1798871-30-3 | 純度 | 98.57% |
|---|---|---|---|
| 分子量 | 633.65 | 分子式 | C??H??F?N?O?S? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-18682 | 應用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 1798871-30-3
MCE 國際站：Centrinone
產(chǎn)品活性：Centrinone (LCR-263) 是選擇性，可逆的 PLK4 抑制劑，Ki 值為 0.16 nM。
研究領(lǐng)域：Cell Cycle/DNA Damage
作用靶點：Polo-like Kinase (PLK)
In Vitro: Centrinone (LCR-263) exhibits more than 1000-fold selectivity for Plk4 over Aurora A/B and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes. Centrinone (LCR-263) treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division, until most cells lack centrioles and centrosomes. Treatment with Centrinone (LCR-263) reduces centriole number in multiciliated Xenopus epithelial cells, which indicates that Plk4 also controls centriole amplification in differentiated cells. Centrinone (LCR-263) treatment causes centrosome depletion in human and other vertebrate cells. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors.
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