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Progesterone

MCE 國(guó)際站：Progesterone

品牌：MedChemExpress (MCE)

貨號(hào)：HY-N0437

CAS：57-83-0

中文名稱：黃體酮； 孕酮

Synonyms：黃體酮; Pregn-4-ene-3,20-dione

純度：99.79%

存儲(chǔ)條件：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

運(yùn)輸條件：美國(guó)大陸的室溫；其他地方可能有所不同。

產(chǎn)品活性：Progesterone是一種類固醇激素，可調(diào)節(jié)月經(jīng)周期，對(duì)懷孕很重要。

體內(nèi)：Progesterone (注射劑；1 毫克；每天連續(xù)注射 3 次) 刺激小鼠子宮內(nèi)膜的血管成熟[4]。 |re| 誘導(dǎo)黃褐斑[6] 致病原理 Progesterone會(huì)增加色素沉著和體重。體重增加被認(rèn)為是由于鈉和液體潴留，這可能會(huì)進(jìn)一步影響合成黑色素的黑素體的細(xì)胞內(nèi)pH 值，進(jìn)而導(dǎo)致黑色素的產(chǎn)生，因?yàn)槔野彼崦富钚耘c細(xì)胞內(nèi) pH 環(huán)境有關(guān)[7]。 具體造模方法 Mouse: 6-8 weeks, female C57BL/6J miceAdministration: 15 mg/kg; Injected intramuscularly, (3 * 3 cm back hair shaved; UVB irradiation (λ = 312 nm, 2 h/day)), daily for 30 days 造模成功指標(biāo) 個(gè)體表型變化：引起皮膚組織損傷，結(jié)痂，皮膚變黑，表皮嚴(yán)重增生，毛囊壞死。組織：纖維組織增生，表皮黑色素細(xì)胞富集。分子：p-JNK /JNK、p-P38MAPK/ P38MAPK表達(dá)&bull。 MCE尚未獨(dú)立證實(shí)這些方法的準(zhǔn)確性。僅供參考。

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參考文獻(xiàn)：

[1]. Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2003 Dec 10;46 Suppl 1:S7-S16. [2]. Zava DT, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998 Mar;217(3):369-78. [3]. Komesaroff PA, et al. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001 Jun;4(2):144-50. [4]. Girling JE, et al. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology. 2007 Nov;148(11):5433-41. Epub 2007 Aug 9. [5]. Wong R, et al. Progesterone pharmacokinetics in the mouse: implications for potential stroke therapy. J Pharm Pharmacol. 2012 Nov;64(11):1614-20. [6]. Wang JY, et al. Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in C57BL/6J mice skin. Acta Cir Bras. 2022 Dec 19;37(10):e371002. [7]. Hisayoshi NoRIMOTO, et al. Effects of keishibukuryoganryokayokuinin (gui-zhi-fu-ling-wanliao-jia-yiyiren) on the Epidermal Pigment Cells from DBA/2 Mice Exposed to Ultraviolet B (UVB) and/or Progesterone. The pharmaceutical Society of Japan. 2011, 131(11):1613-1619.