作者： Ndidi C. Ngwuluka1, Darsheen J. Kotak2, Padma V. Devarajan2

1.Biomaterials and Drug Delivery Unit, Faculty of Pharmaceutical SciencesUniversity of JosJosNigeria

2.Department of Pharmaceutical Sciences and TechnologyInstitute of Chemical TechnologyMumbaiIndia

 

摘要：Colorectal cancer is a global concern, and its treatment is fraught with non-selective effects including adverse side effects requiring hospital visits and palliative care. A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance. Metformin-loaded solid lipid nanoparticles (SLN) were designed, optimized, and characterized for particle size, zeta potential, drug entrapment, structure, crystallinity, thermal behavior, morphology, and drug release. Optimized SLN were 195.01 ± 6.03 nm in size, −17.08 ± 0.95 mV with regard to surface charge, fibrous in shape, largely amorphous, and release of metformin was controlled. The optimized size, charge, and shape suggest the solid lipid nanoparticles will migrate and accumulate in the colon tumor preventing its proliferation and subsequently leading to tumor shrinkage and cell death.