Collagen Type Ⅳ（Ⅳ型膠原抗體）

Collagen Type Ⅳ(Ⅳ型膠原抗體)

廣州健侖生物科技有限公司

Collagen Type IV 是基底膜的主要成分。正常組織CollagenType IV 存在于間質(zhì)和上皮的基底膜。該抗體可用于各種良惡性腫瘤組織中基底膜分布的研究，也可用于研究血管外皮細(xì)胞瘤，血管肉瘤、血管內(nèi)皮瘤這類血管源性腫瘤。

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Collagen Type Ⅳ(Ⅳ型膠原抗體)

【產(chǎn)品介紹】

細(xì)胞定位：基底膜

克隆號：CIV22

同型：IgG1

適用組織：石蠟/冰凍

陽性對照：結(jié)腸癌/皮膚

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時間：30-60min

膠原是一種纖維狀糖蛋白，它是由三股螺旋體形成的α-肽鏈網(wǎng)狀結(jié)構(gòu)。目前已發(fā)現(xiàn)膠原達(dá)10種之多，存在于不同組織。Ⅳ型膠原是構(gòu)成基底膜的重要成分。
正常肝內(nèi)基底膜主要存在于血管、淋巴管、膽管周圍，肝竇壁處缺乏。在肝病時隨炎癥發(fā)展，纖維組織增生活躍，纖維組織生成過程中有大量膠原沉積，各種膠原均有所增加，但其中zui為重要的就是構(gòu)成基底膜的Ⅳ型膠原的增加。目前認(rèn)為，Ⅳ型膠原的測定可作為檢查肝纖維化的近代指標(biāo)。
臨床意義
Ⅳ型膠原是主要用于觀察肝硬化的指標(biāo)，其濃度與肝纖維化程度相關(guān)，可由血清Ⅳ型膠原濃度推測肝硬化的程度。
（1）急性肝炎時，雖然有大量肝細(xì)胞破壞，但因無明顯結(jié)締組織增生，故血清Ⅳ型膠原濃度與健康人無顯著差異。
（2）慢性肝炎、肝硬化、肝癌病人，血清Ⅳ型膠原均明顯增高，其增高程度依此為原發(fā)性肝癌、肝硬化、慢性活動性肝炎、慢性遷延肝炎、急性病毒性肝炎。
鑒別診斷
當(dāng)富含血管基底膜成分的組織器官發(fā)生病變時，亦可出現(xiàn)Ⅳ型膠原及基降解片段的異常而明顯升高，如甲亢、硬皮病、中晚期糖尿病等，臨床上應(yīng)注意鑒別。

Collagen Type Ⅳ(Ⅳ型膠原抗體)

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Collagen Type IV is the main component of the basement membrane. Normal tissue CollagenType IV is present in stromal and epithelial basement membranes. The antibody can be used for the study of the distribution of basement membrane in various benign and malignant tumors and also for the study of angiogenic tumors such as hemangiopericytoma, angiosarcoma and hemangioendothelioma.
Collagen is a fibrillar glycoprotein, which is an a-peptide network formed by the three-helix. It has been found that as many as 10 kinds of collagen, exist in different tissues. Type IV collagen is an important component of the basement membrane.
Normal liver basement membrane exists mainly in the blood vessels, lymphatic, bile duct around the liver sinus wall at the lack of. In liver disease with the development of inflammation, fibrous tissue hyperplasia, fibrous tissue production process has a lot of collagen deposition, a variety of collagen have increased, but the most important of which is the formation of basement membrane type IV collagen increase. At present, the determination of type Ⅳ collagen can be used as a modern indicator of liver fibrosis.
Clinical significance
Type IV collagen is mainly used to observe the indicators of liver cirrhosis, its concentration is related to the degree of liver fibrosis, which can be estimated by the level of serum type Ⅳ collagen.
(1) Acute hepatitis, although there is a large number of liver cell damage, but no significant connective tissue hyperplasia, serum type Ⅳ collagen concentration and no significant difference in healthy people.
(2) Chronic hepatitis, cirrhosis, liver cancer patients, serum type Ⅳ collagen were significantly increased, the higher the degree of primary liver cancer, cirrhosis, chronic active hepatitis, chronic persistent hepatitis, acute viral hepatitis.
Differential diagnosis
When the tissues and organs rich in vascular basement membrane disease occur, there may also be abnormal and significantly increased type Ⅳ collagen and base degradation fragments, such as hyperthyroidism, scleroderma, advanced diabetes, clinically should pay attention to identify.