Cytokeratin 17（細胞角蛋白17）

Cytokeratin 17(細胞角蛋白17)

廣州健侖生物科技有限公司

細胞角蛋白17 分子量為46kDa，表達于復(fù)層上皮和氣管、喉、支氣管假復(fù)層柱狀上皮的基底細胞以及唾液腺的肌上皮細胞。在腫瘤組織中，該抗體主要識別肺、子宮頸和口腔的鱗狀細胞癌。主要用于鱗狀細胞癌的研究。

診斷應(yīng)用：
1． 癌的鑒別
2． 顯示不同上皮樣分化肉瘤的鑒別
1. 滑膜肉瘤
2. 上皮樣肉瘤
3． 肉瘤中的異常染色可為間皮瘤、黑色素瘤、平滑肌肉瘤和內(nèi)皮細胞腫瘤的診斷提供線索，通常只有CK8和CK18（被Cam5.2和35BH11證明）表達陽性，這兩種存在于所有組織中的原始角蛋白胚胎源性表達也許可以解釋CK8和CK18的異位性表達。
4． 在小細胞癌中可以看到細胞核周“圓點狀”染色，如美克爾細胞癌、肉瘤及髓細胞瘤可顯示異常免疫反應(yīng)性。
5． 許多“兒童的小藍圓細胞腫瘤”表達角蛋白，包括尤文氏肉瘤/PNET、橫紋肌肉瘤、腎母細胞瘤和促結(jié)締組織增生性小圓細胞腫瘤。
細胞角蛋白Moll數(shù)
除了表格所列的20種軟角蛋白外，還有限于頭發(fā)、指甲上皮組織的硬角蛋白。細胞角蛋白zui初的分類建立在2D凝膠電泳的基礎(chǔ)上?，F(xiàn)在有特異的單克隆抗體可應(yīng)用于石蠟包埋的組織，由于細胞角蛋白之間的同源性，單抗需十分仔細地篩選以避免交叉反應(yīng)?？乖瓫Q定簇在某些情況下可以被遮蔽，可能反應(yīng)發(fā)生在免疫印跡上而不是在組織切片。

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Cytokeratin 17(細胞角蛋白17)

【產(chǎn)品介紹】

細胞定位：細胞漿

克隆號：Ks17.E3

同型：IgG2b

適用組織：石蠟/冰凍

陽性對照：乳腺/宮頸

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時間：30-60min

Cytokeratin 17(細胞角蛋白17)

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Cytokeratin 17 has a molecular weight of 46 kDa and is expressed on the epithelium of the stratified epithelium and in the trachea, larynx, bronchial pseudostratified columnar epithelium, and myoepithelial cells of the salivary gland. In tumor tissue, the antibody mainly recognizes squamous cell carcinomas of the lung, cervix and mouth. Mainly used for squamous cell carcinoma research.

Diagnostic Applications:
1. Cancer identification
2. Identification of different epithelioid differentiated sarcomas
Synovial sarcoma
2. Epithelioid sarcoma
3. Abnormal staining in sarcomas can provide clues to the diagnosis of mesothelioma, melanoma, leiomyosarcoma and endothelial cell tumors, which are usually only positive for CK8 and CK18 (evidenced by Cam5.2 and 35BH11), both present in all tissues The original keratin-derived expression may explain the ectopic expression of CK8 and CK18.
4. Small cell carcinoma can be seen in the perinuclear "dot-like" staining, such as melanocarcinoma, sarcoma and myeloblastoma can show abnormal immunoreactivity.
5. Many "small blue circle cell tumors in children" express keratin, including Ewing's Sarcoma / PNET, rhabdomyosarcoma, Wilms' tumor, and connective tissue proliferating small round cell tumors.
Cytokeratin Moll number
In addition to the 20 types of soft keratins listed in the table, there is limited to keratin hair and nail epithelium. The initial classification of cytokeratin was based on 2D gel electrophoresis. Specific monoclonal antibodies are now available for use in paraffin-embedded tissues. Due to the homology between cytokeratins, the monoclonal antibodies should be carefully screened to avoid cross-reactivity. Epitopes can be obscured in some cases, and the reaction may occur on immunoblots rather than on tissue sections.