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產(chǎn)品型號27712-1

品牌BPS Bioscience

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Ubiquitination

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產(chǎn)品簡介

●Purchase●DescriptionP22077isacellpermeableinhibitoroftheubiquitin-specificproteaseUSP7(IC50=8

詳情介紹

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Description

P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 µM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50µM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20–40 µM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.

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Synonyms

Ethanone, 1–[5–[(2,4–difluorophenyl)thio]–4–nitro–2–thienyl]–