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Methyltransferases are enzymes that transfer a methyl group from S-adenosylmethionine (SAM) to substrate molecules, such as DNA, RNA, and proteins. In particular, methylation of lysines or arginines in histone tails provides epigenetic regulation of gene expression, in which methyltransferases serve as the “writers" of the methylation code on histones. The degree of methylation and the location of methylation induce conformational changes in chromatin that enable or suppress access by the transcriptional machinery to express genes. DNA methyltransferases modify DNA by adding a methyl group to cytosines. DNA methylation of CpG dinucleotides suppresses gene expression and is critical for transcriptional silencing during imprinting, X-inactivation and other developmental processes. Both histone and DNA methylation play a crucial role in the development of nearly all types of cancer and are targets for therapy.

We offer an extensive selection of RNA, DNA, and histone methyltransferase target screening and profiling services. Our team of experts, using our in-house developed biochemical assay kits, can provide:

• Screening for activity and selectivity across our full panel or just select targets

• Determination of IC₅₀

• Project guidance and questions answered in a timely manner

• Delivery of detailed results promptly and on time

If follow-up studies are required, we can provide the same active proteins as the ones used in our assays.

Available Service Assays

DNA Methyltransferase Biochemical Assays:

Histone Methyltransferase Biochemical Assays:

RNA Methyltransferase Biochemical Assays:

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